The White House gets ready to fight a new variant and the same old Republican Party, Brown University Dean of Public Health Dr. Ashish Jha discusses what we know and don't yet know about Omicron, and actor Kal Penn stops by to chat about his new book, You Can't Be Serious, and play another round of Take Appreciator.

Democrats and journalists still haven't figured out how to handle the threat of another Trump presidency, Senator Chris Murphy joins to talk about Congressional action on gun violence and whether Joe Biden's economic agenda can pass by Christmas, and the White House announces a diplomatic boycott of the 2022 Winter Olympics in Beijing.