Troy and Pickle help rid a citrus grove of pythons. Bill is forced to hunt solo for the day. Meanwhile, Brue and Zak mount an airboat to a new honey hole and Dusty responds to a friend's call for help.

On the last day of the season, the hunters gather to target breeding females. Bill and Tes investigate a secluded stretch of islands. Dusty hopes to go out with a bang, while Zak and Bruce follow an ancient native trail. Troy and Pickle search a dry lakebed that could be a python breeding hot spot.