Hunters return to the Everglades to find the enemy transformed. Giant female pythons have learned to hide from their pursuers, allowing them to breed faster than ever. Now the swampers must dive deep into their secret lairs and remove the beasts before the glades are lost forever.

Ashley and Kaylyn charge onto Bear Ridge; Zak and Bruce answer an urgent call for help; Troy and Tes go into battle to defend a bird sanctuary; Dusty puts on his inventor hat to save the Glades.