The teams unite to storm a hostile site that's rumored to be swarming with pythons. Attacking by land, water and air, the teams deploy buggies, boats and drones to target and eliminate a growing threat to the Everglades.

As the excessive heat begins to wear on the hunters, the King of the Swamp launches a contest to catch the biggest python. Each hunting team uses their local knowledge to devise different strategies, hoping to come home the winner.