Pickle learns to drive an airboat on the fly; Zak and Aaron go after two invasive species at once; Bruce and Kaylyn fight through skin-shredding sawgrass; Dusty tests recipes for a new Everglades culinary sensation.

In the final hunt of the year, the hunters descend on Florida's pristine Lake Elizabeth wetlands and go to battle with pythons gaining a foothold in this vital ecosystem, pushing their limits to safeguard paradise.