Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Bettie Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.