Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, and a risky decision is made to save Steven's life, while brother Justin takes the leap to go to Houston to finally accept help.

11 years later, Melissa has lost 500lbs and saw her weight drop to 137lbs. Now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150lb weight gain. Melissa is at a crossroads; can she find her way?