In the 4th year of his weight loss journey, Sean struggles to get past the loss of his mother and live on his own. Dr. Now intervenes to control his eating for a time, but if Sean can't learn to control himself, he will face dire consequences.

For Milla Clark, after 3 years & 5 surgeries, success would mean beating the odds, and becoming one of Dr. Nowzaradan's most impressive weight-loss patients ever. Failure would mean slipping back to the bedbound life she swore she'd never return to.