Marge encourages Homer to embrace his "You-Only-Live-Once" spirit by inviting an old pen pal to stay with him and cross items off of his "to-do" list from when he was a 10-year old. Meanwhile, Lisa institutes a new honor code at Springfield Elementary. Blackboard: 'My school schedule does not include a bye week'.

Lisa finally makes a new best friend, Isabel Gutierrez, only to discover that she's a Republican and her opponent in the campaign for second grade class representative. Also guest-voicing is Anderson Cooper as himself.