Inspector Gadget, Penny, and Brain are on vacation in the Caribbean. But before they've had a chance to get any serious R & R on Gadget's dilapidated old rust-bucket of a boat, duty calls and Inspector Gadget is back to work.

In Malaysia, the Wild Man of Borneo (a M.A.D. scientist), has both derived a virus from flies and concocted its antidote. A head-cold-suffering Gadget must stop Dr. Claw's plan to turn everyone on the planet into babbling, bubble-blowing imbeciles.