Offered the chance to fulfill his lifelong dream of authoring a book, Niles enlists Frasier to help him pen a guide to healthy sibling relationships. Faced with writer's block and looming deadlines, the two brothers lock themselves in a hotel room until the book is complete, and begin driving each other crazy.

Frasier spends a half hour with Niles at Cafe Nervosa discussing Frasier's first year in Seattle.