The defending AFC champion Chiefs brace for the Bills in a rematch of the 2020 conference title game. Kansas City exploded with a 38-6 run to burst Buffalo's bubble in January behind Patrick Mahomes' three touchdown passes, two to Travis Kelce.

The 49ers try to halt a four-game slide at Levi's Stadium as they welcome the Colts. San Francisco lost both its home games this season by a combined nine points. Indianapolis has won four straight meetings. The 49ers last defeated the Colts in 2001.