The 49ers (4-4) come off a bye week to host the Chargers (5-3). Los Angeles has won four of its past five outings following a three-point win at Atlanta in Week 9. Austin Ekeler (LAC) has 10 touchdowns this year. San Francisco is 2-1 at home in 2022.

The Patriots visit the Vikings for a Thanksgiving night affair. New England last played on the holiday in 2012, when it upended the New York Jets 49-19 in the Butt Fumble game. Minnesota is 6-2 on Thanksgiving after defeating Detroit 30-23 in 2017.