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Summer camp is on the line as Melvin's nanobots find a new host in Captain Underpants, forcing the boys to shrink down and go inside his brain.
A final exam sends George and Harold to the Doom Dome, where they must battle Melvin -- who's been injected with powerful nanobots -- in order to pass.
George and Harold have to keep their grades up to go to summer camp. But it's a tall order with Melvin -- and a cyborg Melvin -- running the school!