When a bloody bride stumbles into Bronx General, Wolf goes to extreme measures in a race against the clock to save her and her missing husband; Ericka and Jacob must find a reason for their John Doe patient not to get transferred out of their care.

When a group of pregnant teen girls turns up at Bronx General, Dr. Wolf and the residents find themselves on a strange path involving friendship bonds and the witchy side of TikTok (called WitchTok). Also, the audience slowly begins to observe who the interns are outside of the hospital walls. Like Dr. Wolf, the foursome have distinct stories and journeys that led them into the medical field.