Tim suddenly starts shaking while examining a patient and can hardly hold on to his balance. Suzanne and Evan are worried about him but Tim just brushes it off. Roger is surprised when he bumps into and old acquaintance at the hospital; Eleanor Riggs, who is an old college girlfriend that he once loved passionately. Roger is excited about seeing her again but then he finds out from Eleanor's former doctor that she suffers from a terminal, inoperable tumor. Trying to compensate as he's probably losing the twin girls, Tim goes to donate his bone marrow to a very sick young boy. However, the kid's doctor, Dr. Grant, refuses to let him go through with it because Tim's blood pressure is way too high. Roger confronts Eleanor about not telling him of her illness. He insists on trying to help her but Eleanor has come to terms with the fact the's going to die and just wants to spend time with Roger instead.

Sarah's patient Patricia Kingsley is close to dying from cancer when Sarah discovers she has a husband, Hugo. Sarah locates Hugo to convince him to be at his wife's deathbed and soon discovers why he has stayed away; Hugo is horribly disfigured (looking a lot like the Elephant Man). Roger is happily surprised when Eleanor unexpectedly reappears. She is getting sicker, though, and Tom Florin says she needs to have the tumor removed right away. To Roger's great relief, Eleanor agrees to the operation; she wants to live so she can be with him. Evan finds Patrick's behavior towards a patient, opera singer Francesca Lucchesi, inappropriate. Francesca has problems with her voice, and Patrick (who seems to have a crush on her) suggests to Evan that she may have tuberculosis like the character she is to play in the LA Opera. Evan gets her to take a test to find out, and Francesca worries. Everyone looks strangely at Hugo but he gets to be with his wife as she dies.