When a young boy's legs are crushed after being pinned by a car, Malik is determined to use a revolutionary procedure using spider silk to save his limbs, while Zoe lobbies in favor of the safer route of amputation. Also, James, Walter and Talaikha care for Amelia, a young woman in dire need of a liver transplant, but they're puzzled by her resistance when they tell her the donor is her estranged father, Simon.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.