2022 was Emmerdale's 51st year. Production was overseen by producers Kate Brooks and Laura Shaw and executive producer Jane Hudson.

Major storylines included Faith Dingle's terminal cancer and her decision to end her life, Chas Dingle's affair with Al Chapman, Cain Dingle taking the blame for his son Kyle Winchester shooting Al dead, Marlon Dingle's stroke, Leyla Cavanagh becoming addicted to cocaine, Nicola King being brutally attacked by a group of girls, Meena Jutla being sentenced to life imprisonment for her murders, Amelia Spencer giving birth to Samson Dingle's baby and Samson's refusal to be involved, Noah Dingle being sent to prison for stalking Chloe Harris, Mackenzie Boyd cheating on Charity Dingle with Chloe and her subsequent pregnancy, the 50th anniversary storm in October that caused the deaths of Harriet Finch and Liv Dingle, the arrival of Cain and Chas' secret brother Caleb Miligan and Arthur Thomas coming out as gay.