Thanos has the Space Gem stolen from him by his older sister Nebula. She uses the Squad Helicarrier's Teleporter to escape, but ends up in the Negative Zone. Wolverine and H.E.R.B.I.E. team up as they were the only ones aboard the Helicarrier at the time. Having just returned from a trip to Six Eggs Over Easy amusement park, Iron Man & Falcon venture into the Zone to save them.

Thanos uses the Mind Gem to control Hulk who goes on a sleepwalking rampage. The Super Hero Squad must enter the dream realm to fight back, even if they have to get help from Nightmare.