Thanos destroys the Nova Corp and takes Nova captive in order to get his hands on the Power Gem. This leads Iron Man to recruit Hercules and She-Hulk to help rescue him. Meanwhile, H.E.R.B.I.E. falls for Nova's messenger droid named Holoball.

Doctor Doom returns to Latveria in hopes to regroup, but discovers that his mother Cynthia "Coco" Von Doom is free from captivity, has brainwashed her captor Chthon, and has turned his castle into a day-spa trap that has ensnared the Super Hero Squad!