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Gia, a grieving writer, decides to write a book about women's desire. In the center is Lina, a housewife in Indiana; Sloane, a glamorous entrepreneur in the Northeastern United States and Maggie, a waitress in North Dakota.
Lina flees from a stagnant marriage and a body filled with pain. She joins a women's group at Dr. Henry's and tries to reconnect with the love of her life while striking up a friendship with Gia.