Bo and Luke assist Texas ranger Jude Emery in tracking down hardened criminal "Snake" Harmon. But they must rely on a little help from their friends (as well as Boss and Sheriff Byrd) when they find themselves kidnapped by Harmon's henchmen.

Bo and Luke accidentally pick up a crate of marijuana at the bus depot and end up on the run - But Mason Dixon, a private detective and his two sexy associates are on to the Dukes but end up working together to stop a drug-smuggling ring.