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The arrival of a new scientist, Zito, sparks off an attack by the Organization to recover the virus and take over Phoenix's servers.
To find out who a new terrorist organization, Omnus, is targeting, Mac is forced to impersonate Murdoc. However, he finds himself getting too deep into the hitman's head. Meanwhile, Wilt and Riley try to find a killer that a couple hired Murdoc to dispose of.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.