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When an old friend of Mac's dies in a lab fire accident at MIIT, he goes to the memorial and Jack tags along. They soon learn that the fire was no accident and that someone wanted Frankie dead.
The team heads to Hawaii when an earthquake strikes Hilo. While Jack and Mac help Chenand Keno of the Five-0 team, Riley works with an attractive IT man to fix the city's cell network and Wilt rescues a dog.
To find out who a new terrorist organization, Omnus, is targeting, Mac is forced to impersonate Murdoc. However, he finds himself getting too deep into the hitman's head. Meanwhile, Wilt and Riley try to find a killer that a couple hired Murdoc to dispose of.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.