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After Jack's former CIA partner is captured on a mission to take down a drug dealer in Caracas, Mac and Riley help him rescue her. Meanwhile, Mac continues looking for a clue to Nikki's whereabouts.
After losing their head of intelligence, special U.S. government agents MacGyver and Dalton recruit a new hacker, Riley Davis, and go looking for a stolen virus that could wipe out millions.
The team heads to Malaysia to capture a terrorist money man, Ralph Kastrati, who can tell the Foundation what the next target is. However, things go awry when a terrorist shoots Ralph in the chest.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.