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Mac goes up against a bomber who killed Mac's CO in Afghanistan... and is now trying to disrupt a UN peace conference.
Mac and his team go aboard a Berlin-to-Frankfurt train to protect an executive assistant who can testify against her crooked boss... who has sent killers to dispose of her before she does.
To find out where a drug lord's base of operations is, Mac has to go into an escapeproof prison to free the man and have him take him to his base. First, Mac has to survive prison life long enough to make contact.
Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.