One of Jack's old Delta buddies comes to him saying that another old buddy needs help. Meanwhile, Matty sends Wilt, Riley, and Leanna on a mission of their own while Jack and Mac are out of the country.

With Jack reporting to the Secretary of Defense and Wilt in LA, Mac and Riley are the closest agents to Georgia when a children's hospital runs out of air and rebel activity prevents anyone from delivering a vital tanker of liquid oxygen. Riley helps MacGyver decide whether or not to allow his father back into his life.