With Jack reporting to the Secretary of Defense and Wilt in LA, Mac and Riley are the closest agents to Georgia when a children's hospital runs out of air and rebel activity prevents anyone from delivering a vital tanker of liquid oxygen. Riley helps MacGyver decide whether or not to allow his father back into his life.

Murdoc abducts Nasha as leverage to force Mac to help him recover his kidnapped son Cassian. As the two men work together, Mac gets an up-close view on the sociopathic killer... and his equally amoral wife.