A vial with a deadly virus goes missing from the CDC, and Mac, Wilt, and Jack are called in to investigate. Meanwhile, Billy takes Riley on a cross-country drive and promises a surprise at the end, but their car is stolen.

A mysterious captor takes Jack and Mac captive while they're on their way to Las Vegas for their yearly Maniversary. Meanwhile, Matty sends Wilt, Riley, and Leanna on a mission to copy data inscribed on a diamond belonging to the niece of a terrorist.