After a senator contacts her about his being blackmailed, Matty sends the team on an off-the-books mission to Ghana to recover the senator's hard drive... which also has a secret file named Dragonfly on it.

A vial with a deadly virus goes missing from the CDC, and Mac, Wilt, and Jack are called in to investigate. Meanwhile, Billy takes Riley on a cross-country drive and promises a surprise at the end, but their car is stolen.