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Vash and Wolfwood enter a quick-draw competition in May City, if one of them wins, the prize money goes to a poor local family. Unfortunately, they're both in the line of fire - the contest is rigged!
During a bus trip to May City, Vash, Meryl and Milly encounter a priest named Nicholas D. Wolfwood. Before too long, the travelers find their journey interrupted by a horde of attacking robotic spiders.
Things get complicated when the gang gets tangled up in the drama surrounding a runaway dancing girl and the son of a caravan owner.