After years of drinking with the guys, Peter's love of the sauce has finally caught up with him and he needs a kidney transplant. Brian offers him one of his, but will a canine kidney be compatible? Meanwhile, Meg and Chris collaborate on a poem to celebrate a very important visitor.

After a public disturbance, Peter and Brian are forced to attend a 12-step meeting to help kick their drinking problems. Unable to recognize his issue, Peter gets a visit from Death, who gives him a glimpse of what life would be like with and without "Mr. Booze" in his bloodstream.