The Big Brother production will follow specific health and safety protocols for COVID-19 with the welfare of everyone involved as the highest priority. Houseguests will undergo a quarantine period prior to production and will be tested several times prior to entering the House. Once inside, they will be tested weekly during the season and have no contact with any crew members, and all supplies delivered will be disinfected. In addition, the live show will not have a studio audience.

All staff and crew members will be tested prior to commencing work on a regular basis, as well as screened daily for symptoms. They'll be required to wear PPE and will work in pods to enhance social distancing. In addition, a COVID-19 compliance officer will be on staff to monitor and enforce all health and safety COVID-19 protocols.