A medical drama centering on first-responder paramedics at a San Francisco hospital and the extreme dangers they face to save lives. In the series opener, a tragedy impacts the team directly---and permanently.

A man goes on a shooting spree inside an office building, and the ensuing hostage situation impacts Boone directly. The crisis forces Rabbit and Nancy to work together for the first time in more than a year. Meanwhile, Marisa notices she has more in common with Rabbit than she thought.