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A sniper on the loose in San Francisco places Nancy and Glenn in harm's way. Meanwhile, Rabbit and Marisa struggle to follow protocol, and Boone works on adjusting to Tyler's new paramedic status.
Rabbit's therapy starts to pay off when he recalls a traumatic occurrence from his past. Meanwhile, a patient suffers because of Nancy and Diana's opposing opinions; Glenn achieves a career milestone; and Boone and Tyler think about their futures.
Nancy goes against procedure when treating a cheerleader, which puts her relationship with Joe at risk when he suffers the consequences of her actions. Meanwhile, Rabbit and Marisa are exposed to meningitis and must be quarantined; a misunderstanding results in tension between Boone and Tyler.