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Ashley receives an ultra-religious patient who is willing to put himself at peril to appease God, forcing Ashley to reconsider her own religious past. Naz supports a pregnant patient through the hardest decision of her life.
Ashley and Caro explore past relationships. Keon grapples with Molly's attempts to sideline him. Naz tries to balance her emotional connection to a patient with his medical needs. Wolf is forced to leave his comfort zone and care for a newborn baby.
Keon finds himself supporting his patient's fiancée when a swift recovery has an unexpected side effect. Naz treats a former Olympian whose rare condition requires creative solutions; Wolf helps a frequent flyer with hearing loss.
Nurses follows four young nurses working on the frontlines of St. Jude's hospital dedicating their lives to helping others, while figuring out how to help themselves.