Ronen's mysterious lump above his knee is one of the largest Dr. Lee has ever seen. Amber suffers from a debilitating skin disease that no one understands. Sandy has a neck lump she calls Tommy. Kristy's eyelid cyst is ruining her life.

Diane has thousands of tumors all over her body that have ruined her life. Will fears his shoulder lump will be ripped open at work. Anthony's daughters force him to get his lump examined and Kal Elle detests her hideous varicose veins.