Matt has a skin condition that causes tumors to grow all over his body. Yamileth hasn't pursued her dreams because of the lump on her neck. Pat is covered with dark spots from her neck to her abdomen. Jennifer has a unicorn bump on her forehead.

Amber has hundreds of tumors on her face; Antonio has a mound on his spine and is afraid it might be impossible to remove; sisters Cheri and Janice both suffer from possibly matching lumps; Tatiana has an embarrassing bump on her butt cheek.