Elizabeth's head is covered with giant cauliflower-shaped bumps. Jamaal has been growing a strange knob on the left side of his butt since he was just a boy. Donna's cracking, bleeding skin condition has aged her face and kept her from being social.

Bob suffers from mysterious open-wound sores all over his body; Virginia's stress-ball-sized lump is such a pain in her neck that she can't wait to have it removed; Ted suffers from flaking, itchy, stucco-like skin and has had no luck finding a cure.