Host Don Wildman travels the country inspecting a 100-year-old tissue sample that sent a doctor to the gallows, a collection of birds killed by a mysterious epidemic and the kettle used by a group of settlers to cook up a ghastly stew.

Don Wildman examines sketches that depict otherworldly creatures said to have descended upon a Kentucky farm, a set of brass knuckles that protected a great president from a nefarious plot, and a building tied to a man's strange disappearance.