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The surgery is chaotic, with both Martin and Louisa now practising from it. Bert's new business venture with Al doesn't get off to a good start, and Penhale suspects noise complaints are due to paranormal activity.
After having his career scrutinised by the General Medical Council because of his blood phobia, Martin makes efforts to overcome his fear and begins to question whether he made the right decision about resigning.
Morwenna is back as receptionist and the Ellinghams have a new dog. Martin attends Stewart's survival course, but not as a participant like Al and Penhale. Louisa agrees to help Pippa by speaking at the school assembly alongside Mrs Tishell.
The final series sees the Doc making efforts to overcome his phobia, and beginning to question whether he made the right decision about resigning. He and Louisa have also welcomed a baby daughter, Mary Elizabeth, a sister for four-year-old James Henry.