Dr. Anthony Fauci, White House Chief Medical Advisor and Director of the National Institute of Allergy and Infectious Diseases (his first appearance); this special episode marked the first anniversary of the last show from the Ed Sullivan Theater on March 12, 2020. Steven describes this episode: "A Late Show Quaranniversary Special: The Year That Took 100 Years But Was Also Somehow One Long Day."

Actress Lupita Nyong'o; actor Martin Freeman.