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USAID Administrator Samantha Power; musical performance by Maroon 5; special appearance by Seth Rogen. This is the last "A Late Show" due to the COVID-19 quarantine.
Actor Samuel L. Jackson; TV personality Padma Lakshmi.
Comedian Jon Stewart; musical performance by Oscar-winning artist Jon Batiste; special appearance by comedian Dana Carvey; special appearance by Evelyn Colbert, Stephen's wife. The show returns to the Ed Sullivan Theater with the first live studio audience, fully vaccinated, since March 12, 2020. To date, "A Late Show" has produced 211 episodes remotely since leaving the theater, 15 of them live.