In the opening episode, Marshall Cuso shows up in NYC with a mushroom that can cure any disease or injury, and bumps into his old classmate, Frances. But what Marshall doesn't realise is that Frances works for Reutical, a big pharmaceutical company.

Marshall buys a plot of land near a chemical waste site with a plan to grow more mushrooms. Meanwhile, Frances rushes home from Europe after a huge development. Copano and Harrington investigate a connection between Marshall and Frances.