Rugby player Luke from Hull has Tourette's syndrome and finds it hard to control his physical and vocal tics. With a job as a chef, a degree in science and health, and a great set of friends, Luke believes finding a girlfriend is the final piece of the puzzle. Bookseller Sam from Cambridgeshire longs for the romance he reads about in novels. Sam has Asperger's. He is gay and finds the scene intimidating, but is ready to put himself out there. Photography graduate Becky from north London is a self-confessed romantic. Becky has scoliosis, a genetic condition that causes a curvature of the spine. Becky has never had a boyfriend, but is determined to do something about it.

The love-seekers this time include Amber, who suffered a major stroke eight years ago. Having learned to walk and talk again, Amber's ready to find her Prince Charming. There's also Nick and Richard.