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Timmy accidentally wishes himself into a girl before Trixie's birthday party, and she uses her new feminine mind to get the perfect gift for her. However, it turns out that she likes boy stuff, too.
Timmy, tired of losing every game because of Chester, wishes that Chester would become a skilled baseball player, but Chester gets on Timmy's nerves when he starts hogging every position and shunning the rest of his team.
Mark Chang returns to take Vicky with him, which Timmy is happy about, but his parents find him a new baby sitter. As a result, Timmy must go to Flappy Bob's Peppy Happy Learnatorium, where everything is boring (like having to watch an eight-hour documentary on moles and how smacking them in a game could lead them to extinction when he attempts to play a whack-a-mole game), too safe (unnecessary safety gear in a ball pit) and healthy (soy cubes). Timmy must now escape and get Vicky back.