Timmy is tired of the normal everyday routine, and how he never gets any rescuing from his enemies. After a very bad day, he wishes that the world was like a comic book. As a result, everybody has a superpower, thus turning the good and Timmy into superheroes and the bad including his nemesises, into supervillains. These supervillains, including Bull-E (Francis), The Babyshredder (Vicky), and Dr. Crocktopus (Mr. Crocker), are then recruited by the Nega-Chin (who was unleashed with the wish) to attempt to wreak havoc. Timmy then tries to unwish his wish, only to find that his wish has been apparently manipulated by the villains (who sense some kind of magic in his "Superhounds", Cosmo and Wanda in reality), so while they can keep their powers, the superheroes cannott. They then take these "Superhounds" away, leaving Timmy and his friends, including the Crimson Chin, to plan what to do next. They end up infiltrating the evil lair with the help of some "everyday heroes", including a firefighter, a janitor, and a milkman who did not help him before when he needed help in everyday situations. He learns a lesson about how people do not have to have powers to be heroes.

Timmy, Cosmo, and Wanda find that FairyWorld has been taken over by a bunch of Pixies, and have to save FairyWorld by themselves.