With remarkable access to the University Hospitals Birmingham - one of Britain's leading NHS trusts - this new series features some of the most ground-breaking surgical procedures being performed in the UK. Each life-saving or life-changing operation involves split-second decision-making against a constant risk to life. Sajid has a massive aneurysm just above his heart that could burst at any moment. And if it bursts, he would bleed to death. Margaret needs an urgent operation to remove a tumour from the lining of her brain. 

Syed's life hangs in the balance as his testicular cancer has spread into his heart. If the tumour dislodges, it could block prove fatal. Consultant urological surgeons undertake a radical plan with the monumental task of removing the tumour, along with help from the cardiac surgeons. In the thoracic theatres, surgeon prepares to operate on 77-year-old David. Last year, David underwent surgery in another hospital to remove cancer from his rib, but tests revealed that the disease is growing back. Renal surgeons prepare to perform a life-changing kidney transplant. Mark had his kidneys removed due to kidney disease, leaving him entirely reliant on dialysis to survive. His half-brother James voluntarily undergoes surgery to donate his kidney and give Mark his life back.