Syed's life hangs in the balance as his testicular cancer has spread into his heart. If the tumour dislodges, it could block prove fatal. Consultant urological surgeons undertake a radical plan with the monumental task of removing the tumour, along with help from the cardiac surgeons. In the thoracic theatres, surgeon prepares to operate on 77-year-old David. Last year, David underwent surgery in another hospital to remove cancer from his rib, but tests revealed that the disease is growing back. Renal surgeons prepare to perform a life-changing kidney transplant. Mark had his kidneys removed due to kidney disease, leaving him entirely reliant on dialysis to survive. His half-brother James voluntarily undergoes surgery to donate his kidney and give Mark his life back.

Claire has a tumour growing at the bridge between her brain and her nose. If left untreated, the tumour will spread into her brain and kill her. Surgeon Shahz Ahmed must act quickly. Getting the cancer out safely is only half the battle. If he can't mend the hole he has to make in Claire's skull to get the tumour out, she could develop meningitis. And Alan needs an equally complex procedure that carries a risk of death. One of his heart valves is severely damaged, leaving him with just months to live as his heart struggles to pump enough blood throughout his body. Surgeon Moninder Bhabra must delve deep inside Alan's heart to delicately repair the valve.