Sipowicz and Clark investigate the murder of an irrational female Corrections Officer who tempted fate. What at first seems like a clean murder becomes murky when Clark learns her own disturbed mental state may have played a part in her own murder. After realizing she was murdered for her weapon, despite her mild lunacy, Clark makes the right decision and puts the shooter away. Meanwhile, McDowell is assigned a new partner, none other than Eddie Gibson, a detective who has a reputation for being incompetent. The two investigate the murder of another woman who may have been a victim of spousal or maternal abuse, with a surprising twist. When they learn she was both an alcoholic and suffered from multiple sclerosis, the killer turns out to be from her own family.

The entire Fifteenth is on the case of a baby missing from a maternity ward, and Medavoy and Jones track an arsonist suspected of a hate crime when a store owned by two Arab brothers is burned down. Andy finds out Eddie has a serious health issue and agrees to partner with him. Connie begins following a young woman for no apparent reason.